Darja
Ovarian or egg reserve is the pool of eggs that a woman has at any given moment. Women are born with about half a million eggs. From that moment on, we keep losing them – throughout our fertile life, eggs are lost at a rate of approximately 1,000 per month.

As women age, various kinds of damage such as genetic mutations and deletions accumulate within eggs making them less functional and capable of making healthy babies. At some point, typically after the age of 37, many women become diagnosed with a “diminished ovarian reserve”.

Although it sounds like a disease, it’s important to understand that there is no real illness behind having a low egg reserve. It’s only a simple, unavoidable biological aging that is similar to the term “infertility”.

Although we have got used to viewing infertility as a diagnosis, in most cases it’s a self-imposed problem.

In reality, almost all women have been fertile in their twenties. Only they have let this reality slip away without taking advantage of it, in terms of either having babies, or freezing their eggs for a later stage.

Darja
Thank you for this question. There is really a tremendous lack of understanding about fertility in women.

This goes for all levels of education – even well educated women are often unaware of the realities of their biological clock. Let me give you one example.

A few years ago, a good friend of mine was shocked to find out that she could not get pregnant with her own eggs any more. As a matter of fact, she was unpleasantly surprised to hear she had any eggs – she told me that it made her feel like a hen and she didn’t like anything about her to be defined in biological terms.

My friend at that time was 38, with a PhD in social sciences (and together with her partner for almost 20 years).

The fact is, women have started having babies late.

That’s why society needs to adapt to this new trend. Best would be, we teach teenage girls in schools about their reproductive choices and realities and not just about hygienic management of periods and how not to get pregnant.

Darja
In order to estimate the remaining egg reserve, it’s important to understand a biological reality that young women have good eggs, as opposed to eggs of older women, which generally have lower quality and miscarriages are more frequent. This means that a single most important marker of ovarian reserve is the age of a woman.

In my opinion, every woman over 30 who did not conceive after 6 months of attempting pregnancy should find out where she stands and test her ovarian reserve.

The first and the most important hormone to determine is the AMH level (Anti-Müllerian hormone).

AMH can be tested in the blood on any day of the cycle. AMH is produced by the cells which surround eggs, so its value tells a lot about how many eggs are still available in the ovaries.

Women also need to ask their gynaecologist to find out their antral follicle counts (commonly known as an AFC number). This is an easy-to-perform ultrasound check that tells how active and vital their ovaries generally are and what is going on on their surface on any given day. Antral follicles are best counted towards the end of one cycle and the beginning of the next.

The third important reproductive hormone is the FSH (Follicle-Stimulating-Hormone). In a descriptive sense, its level tells you how hard a body needs to work in order to make your follicles mature and ovulate.

FSH is best measured at the beginning of a cycle. Together, it means that if you visit your gynaecologist at the beginning of the cycle and ask the right questions, you will have all the answers in a single blood test and in a very short time.

Darja
Raising fertility awareness for the generations of girls living in Western societies is essential because infertility rates in women in the developed world are increasing. This will have far-reaching medical and societal consequences. Let me illustrate this with an example from my family:

My grandmother delivered my dad after she turned 40. He was her seventh child.

So I thought I could easily have a baby at 40 years of age, and never questioned the fact that some other women from my family were less fortunate. My own mother, stopped her period at 41, but never talked about it or considered it important, because her family plans were completed already when she was in her twenties.

This is not to say that an early menopause is strictly genetically determined. However, we now know that there is a significant and individually variable genetic component in age of menopause onset, as well as many other aspects of fertility.

And young women need to hear that.

For many decades, women were taught from an early age on how to NOT get pregnant. This is of course important and something that young women need to know. But as a result of this practice, we now have a fast-growing population of first mothers in the age group of over 40.

For some women, this strategy will work. For many more, it will mean regrets and very expensive fertility treatments.

That’s why teenage girls should, in addition to knowing how to avoid unplanned pregnancy, be taught how to master their cycle and be able to answer the following questions:

How to tell when ovulation has occurred?

How does it feel to NOT be able to get pregnant?

How devastation and regret of women who missed a chance to become mothers impact their relationships and careers?

How much do fertility treatments cost and how do couples pay for them?

Is life after infertility ever the same?

These issues need to be addressed in schools in addition to being discussed in the families.

Darja
First, it’s important to never panic about any single readout of a lab result.

It’s only a number, and only when put together with several other numbers and, importantly, by a person who has a lot of experience in a complex field of reproductive endocrinology, will it turn into a diagnosis.

And the good news is, most infertility diagnosis can nowadays be overcome, given the couple has enough time to deal with it.

Darja
In today’s world, women in their mid 20s are putting off starting a family in favour of going to college, starting a career, or traveling the world. This is good and will probably not change any time soon.

However, they should know that the older you get, the harder it is to conceive. That’s why I would recommend to any young woman to either plan to have her first child before the age of 29 or to freeze her eggs for later. Or both.

If I had a daughter, I would definitelly pay for her to freeze her eggs (laughs). Honestly, I would actually see it as a reasonable investment in my own grandchildren.

Egg freezing is a relatively new technique and the only one so far available to women to at least partially preserve their fertility. I would also tell my daughter, to read this interview I made with an embryologist from an IVF lab on when women should start having babies and why.